With contagious infections, it is impossible to trace to "Patient Zero", the very first patient to get the infection.
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Yes, the Bubonic plague whad hit an epidemic before 1564 and was winding down by 1616.
many revolts followed plague. It changed it socially and economically.
John Cabot was the first person to explore the new world for England.
Kent County Council after the black plague
not verry clean