The concept of federalism as expressed in the structure of the US government is best described as a concept of the separation of powers. The Constitution mandated three branches of government in order to avoid power being concentrated on any one entity.
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separation of powers -apex
A constitutional amendment is proposed and submitted to the states for approval
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It can only be changed by passing another constitutional amendment. The best example of this is the 18th amendment, which was later overturned by passage of the 21st amendment. (These amendments related to prohibition and then the repeal thereof.)
Tenth Amendment to the U.S. Constitution "The powers not delegated to the United States by the Constitution, nor prohibited by it to the states, are reserved to the states respectively, or to the people."FEDERALISM