The Native Americans suffered the most during the Era of European Exploration. The Native Americans could not withstand the European wars nor their way of life.
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smallpox, chicken pox, diptheria, typhus, influenza, measles, malaria and yellow fever. All of the above were brought to the Americas during the age of exploration and was a major contributing factor to the genocide of the indigenous peoples.
MESTIZOS are people of mixed European and Indigenous descent in Latin America.
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People from Europe came to America for various reasons, including economic opportunities such as land ownership, trade, and resources. Some sought religious freedom and political autonomy, escaping persecution and seeking a fresh start. Others were driven by curiosity and the spirit of exploration, hoping to discover new lands and establish colonies for their respective countries. Overall, the motivations for European exploration and colonization of America were complex and multifaceted.
I think you mean the indo-Europeans. The term 'Indo-European' refers in most cases to a group of languages with common linguistical roots, not so much to people. There are some 450 languages today with Indo-European roots, European languages like English, Spanish, German and Russian just being four of them. Almost half the people on this planet speak an Indo-European language. The "Indo"-part of the name is caused by the fact that several eastern languages, notably Indian and Iranian dialects and languages, have the same roots as most European languages.