What was albrecht Durer's most famous painting?

Answer 1

the Praying Hands Answer 2: I would say either the self-portrait of 1500, or 'Four Apostles' of 1525. The gray and white brush DRAWING on blue-grounded paper, entitled the "Hands of the Apostle," generally known as "The Praying Hands, is not a painting.

Answer 2

Durer was most well known for his printmaking works. His Rhinosaurous print is among the most famous of his prints.