secretary of state
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Yes ,William Henry Harrison was the first president to die while in office. He died in the White House after catching a cold.
Henry clay.
John Quincy Adams was the benefactor of what Jackson people called the corrupt bargain. In return for his election, he appointed Henry Clay secretary of state.
The House of Representatives chose the president in early 1825, since no one got a majority of the electoral votes. Henry Clay had won three states: Kentucky, Missouri and Ohio which placed him 4th and removed him from consideration as president. He was speaker of the House and so was influential there. His views seemed closer to Jackson's than to Adams', but his three states all voted for Adams. After Adams won and appointed Clay as his secretary of state, jackson supporters believed that Clay had made a deal, making Adams president in exchange for his becoming secretary of state. In those days, secretary of state was considered to be a stepping stone to the presidency and Clay clearly wanted very much to be president.
The 9th President of the United States William Henry Harrison was the first to die in office in 1841 only 32 days into his term.