There were quite a few of them:
Masaccio, Fra Angelico, Filippo Lippi, Botticelli, Leonardo da Vinci.
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Jan van Eyck.
in the early 15th century
yes, there was. Pieter vanHuys was a Flemish artist who lived 1519 to 1584 (16th Century). He did not paint " the Chess Players" as found in Perez-Revete's novel the Flanders Panel. Beatrice of Burgundy lived in the 13th Century and there was no Ferdinand nor Roger de Arras.
Albrecht Dürer worked 15th - 16th centuries.
During the renaissance 15th- 16th century